Endothelium is strategically located at the interface between blood and interstitial tissues,
placing thus endothelial cell as a key player in vascular homeostasis. Endothelial cells are …

Abstract von Willebrand factor (VWF) is a long plasma protein that contains many domains
and each domain has its own function. VWF exists in a multimeric form and performs …

In the majority of patients with acquired thrombotic thrombocytopenic purpura (TTP),
antibodies are directed toward the spacer domain of ADAMTS13. We have previously …

Proteolytic processing of von Willebrand factor (VWF) by ADAMTS13 metalloproteinase is
crucial for normal hemostasis. In vitro, cleavage of VWF by ADAMTS13 is slow even at high …

Endothelial cells are reported to contain several distinct populations of regulated secretory
organelles, including Weibel-Palade bodies (WPBs), the tissue plasminogen activator (tPA) …

BACKGROUND: The uptake and processing of blood coagulation factor VIII (FVIII) by
antigen-presenting cells and the subsequent presentation of FVIII-derived peptides to CD4+ …

Objective—Endothelial cells store VWF (von Willebrand factor) in rod-shaped secretory
organelles, called Weibel-Palade bodies (WPBs). WPB exocytosis is coordinated by a …

Although the liver is known to be the main site of factor VIII (FVIII) production, other organs
are probably also important for the regulation of FVIII secretion. However, the study of the …

Background: Low‐density lipoprotein (LDL) receptor family members contribute to the
cellular uptake of factor VIII. How von Willebrand factor fits into this endocytic pathway has …

Endothelial cells, forming a monolayer along blood vessels, intricately regulate vascular
hemostasis, inflammatory responses, and angiogenesis. A key determinant of these …