BACKGROUND Proteins are synthesized on ribosomes as linear chains of amino acids and
must fold into unique three-dimensional structures to fulfill their biological functions. Protein …

Although scalar-coupling provides important structural information, the resulting signal
splittings significantly reduce the resolution of NMR spectra. Limited resolution is a particular …

Protein–ligand interactions are of fundamental importance in almost all processes in living
organisms. The ligands comprise small molecules, drugs or biological macromolecules and …

Amyloid proteins are involved in many neurodegenerative disorders such as Alzheimer's
disease [Tau, Amyloid β (Aβ)], Parkinson's disease [alpha-synuclein (αSyn)], and …

The ubiquitin-proteasome system (UPS) is a crucial protein degradation system in
eukaryotes. Herein, we will review advances in the understanding of the role of several …

As the population is aging, the incidence of age-related neurodegenerative diseases, such
as Alzheimer and Parkinson disease, is growing. The pathology of neurodegenerative …

Polyglutamine expansion in the huntingtin protein is the primary genetic cause of
Huntington's disease (HD). Fragments coinciding with mutant huntingtin exon1 aggregate in …

The aggregation of α-Synuclein (α-Syn) into amyloid fibrils is the hallmark of Parkinson's
disease. Under stress or other pathological conditions, the accumulation of α-Syn oligomers …

Despite comprehensive research efforts over the last decades, the pathomechanisms of age-
related macular degeneration (AMD) remain far from being understood. Large-scale …

Caenorhabditis elegans comprises unique features that make it an attractive model
organism in diverse fields of biology. Genetic screens are powerful to identify genes and C …