Structural design of biosensor: A review

J Lopez Dino - Instituto de Ingeniería y Tecnología, 2023 - cathi.uacj.mx
The basic elements in biosensors are the recognition element, reporting element, and
measuring device. The typical structure for the biosensing process to occur is the one where …

Proteasome activation: A novel strategy for targeting undruggable intrinsically disordered proteins

Q Yu, Z Wang, Y Tu, Y Cao, H Zhu, J Shao… - Bioorganic …, 2024 - Elsevier
Intrinsically disordered proteins (IDPs) are characterized by their inability to adopt well-
defined tertiary structures under physiological conditions. Nonetheless, they often play …

Cell-Based Covalent-Capture Deubiquitinase Assay for Inhibitor Discovery

MN Doleschal, J Miller, S Jain… - ACS Pharmacology & …, 2024 - ACS Publications
Ubiquitination is a post-translational modification that elicits a variety of cellular responses.
Deubiquitinases (DUBs) remove ubiquitin moieties from proteins and modulate cellular …

Discovery and Design of Novel 20S Proteasome Activators for Targeted Protein Degradation and Their Evaluation in Neurodegeneration Models

SD Staerz - 2024 - search.proquest.com
In cells, proteostasis is a constant and highly choreographed process that maintains a
balance between the synthesis and degradation of proteins. The ubiquitin-proteasome …