Western lifestyles cause a low-grade but chronic and metabolic inflammation (or
metaflammation), which might prime committed cell lineages to initiate colon tumorigenesis …

Although the concept of cancer stem cells is still controversial, previous studies have shown
that blood cancers, as well as specific types of solid cancers such as colorectal cancer, rely …

Oncogenic mutations that drive colorectal cancer can be present in healthy intestines for
long periods without overt consequence1, 2. Mutation of Adenomatous polyposis coli (Apc) …

The origins of colorectal cancer have long been a subject of intense debate. Early
observations noted cancer formation in the human gut slightly above the base of crypts, the …

Colorectal cancer (CRC), one of the most common tumors in the world, is generally
proposed to be generated from intestinal stem cells (ISCs). Leucine-rich repeat-containing G …

Inflammatory bowel disease is triggered by abnormalities in epithelial barrier function and
immunological responses, although its pathogenesis is poorly understood. The dextran …

Defining consequential differences in intestinal epithelial stem cells in healthy humans
versus those with inflammatory bowel disease (Crohn's disease and ulcerative colitis) is …