Mitochondria are highly dynamic, maternally inherited cytoplasmic organelles, which fulfill
cellular energy demand through the oxidative phosphorylation system. Besides, they play an …

Neurons are markedly compartmentalized, which makes them reliant on axonal transport to
maintain their health. Axonal transport is important for anterograde delivery of newly …

Mitochondrial diseases are a group of genetic disorders that are characterized by defects in
oxidative phosphorylation and caused by mutations in genes in the nuclear DNA (nDNA) …

Mitochondria are highly dynamic organelles whose functions are essential for cell viability.
Within the cell, the mitochondrial network is continuously remodeled through the balance …

Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …

The regulation of mitochondrial dynamics by the GTPase OPA1, which is located at the inner
mitochondrial membrane, is crucial for adapting mitochondrial function and preserving …

Mitofusins (MFNs) promote fusion-mediated mitochondrial content exchange and
subcellular trafficking. Mutations in Mfn2 cause neurodegenerative Charcot-Marie-Tooth …

Summary Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and in the
maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages …

Mitochondria are dynamic organelles that continually move, fuse and divide. The dynamic
balance of fusion and fission of mitochondria determines their morphology and allows their …

Mitochondria are dynamic organelles that play a key role in energy conversion. Optimal
mitochondrial function is ensured by a quality-control system tightly coupled to fusion and …