Ecology and genomics of Actinobacteria: new concepts for natural product discovery

DA van Bergeijk, BR Terlouw, MH Medema… - Nature Reviews …, 2020 - nature.com
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …

Molecular regulation of antibiotic biosynthesis in Streptomyces

G Liu, KF Chater, G Chandra, G Niu… - … and molecular biology …, 2013 - Am Soc Microbiol
Streptomycetes are the most abundant source of antibiotics. Typically, each species
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …

[HTML][HTML] Recent advances in understanding Streptomyces

KF Chater - F1000Research, 2016 - ncbi.nlm.nih.gov
Abstract About 2,500 papers dated 2014–2016 were recovered by searching the PubMed
database for Streptomyces, which are the richest known source of antibiotics. This review …

[HTML][HTML] Activation of microbial secondary metabolic pathways: Avenues and challenges

B Baral, A Akhgari, M Metsä-Ketelä - Synthetic and Systems Biotechnology, 2018 - Elsevier
Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …

The regulation of the secondary metabolism of Streptomyces: new links and experimental advances

GP Van Wezel, KJ McDowall - Natural product reports, 2011 - pubs.rsc.org
Covering: up to early 2011 Streptomycetes and other actinobacteria are renowned as a rich
source of natural products of clinical, agricultural and biotechnological value. They are being …

Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork

C Hertweck, A Luzhetskyy, Y Rebets… - Natural product …, 2007 - pubs.rsc.org
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork Page 1
REVIEW www.rsc.org/npr | Natural Product Reports Type II polyketide synthases: gaining a …

CRISPR-Cpf1-assisted multiplex genome editing and transcriptional repression in Streptomyces

L Li, K Wei, G Zheng, X Liu, S Chen… - Applied and …, 2018 - Am Soc Microbiol
Streptomyces has a strong capability for producing a large number of bioactive natural
products and remains invaluable as a source for the discovery of novel drug leads. Although …

Signals and regulators that govern Streptomyces development

JR McCormick, K Flärdh - FEMS microbiology reviews, 2012 - academic.oup.com
Streptomyces coelicolor is the genetically best characterized species of a populous genus
belonging to the gram-positive Actinobacteria. Streptomycetes are filamentous soil …

Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074

C Olano, I García, A González… - Microbial …, 2014 - Wiley Online Library
S treptomyces albus J 1074 is a streptomycete strain widely used as a host for expression of
secondary metabolite gene clusters. Bioinformatic analysis of the genome of this organism …

Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

KS Hwang, HU Kim, P Charusanti, BØ Palsson… - Biotechnology …, 2014 - Elsevier
Streptomyces species continue to attract attention as a source of novel medicinal
compounds. Despite a long history of studies on these microorganisms, they still have many …