The meter of metabolism
CB Green, JS Takahashi, J Bass - Cell, 2008 - cell.com
The circadian system orchestrates the temporal organization of many aspects of physiology,
including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic …
including metabolism, in synchrony with the 24 hr rotation of the Earth. Like the metabolic …
Molecular components of the circadian clock in mammals
JS Takahashi - Diabetes, Obesity and Metabolism, 2015 - Wiley Online Library
The circadian clock mechanism in animals involves a transcriptional feedback loop in which
the bHLH‐PAS proteins CLOCK and BMAL1 form a transcriptional activator complex to …
the bHLH‐PAS proteins CLOCK and BMAL1 form a transcriptional activator complex to …
Astrocytes regulate daily rhythms in the suprachiasmatic nucleus and behavior
Astrocytes are active partners in neural information processing [1, 2]. However, the roles of
astrocytes in regulating behavior remain unclear [3, 4]. Because astrocytes have persistent …
astrocytes in regulating behavior remain unclear [3, 4]. Because astrocytes have persistent …
[HTML][HTML] Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm
Period determination in the mammalian circadian clock involves the turnover rate of the
repressors CRY and PER. We show that CRY ubiquitination engages two competing E3 …
repressors CRY and PER. We show that CRY ubiquitination engages two competing E3 …
Crystal structure of the heterodimeric CLOCK: BMAL1 transcriptional activator complex
The circadian clock in mammals is driven by an autoregulatory transcriptional feedback
mechanism that takes approximately 24 hours to complete. A key component of this …
mechanism that takes approximately 24 hours to complete. A key component of this …
Cell autonomy and synchrony of suprachiasmatic nucleus circadian oscillators
JA Mohawk, JS Takahashi - Trends in neurosciences, 2011 - cell.com
The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of the master circadian
pacemaker in mammals. The individual cells of the SCN are capable of functioning …
pacemaker in mammals. The individual cells of the SCN are capable of functioning …
Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production
Glucocorticoid (GC) is an adrenal steroid with diverse physiological effects. It undergoes a
robust daily oscillation, which has been thought to be driven by the master circadian clock in …
robust daily oscillation, which has been thought to be driven by the master circadian clock in …
Bmal1 function in skeletal muscle regulates sleep
JC Ehlen, AJ Brager, J Baggs, L Pinckney, CL Gray… - Elife, 2017 - elifesciences.org
Sleep loss can severely impair the ability to perform, yet the ability to recover from sleep loss
is not well understood. Sleep regulatory processes are assumed to lie exclusively within the …
is not well understood. Sleep regulatory processes are assumed to lie exclusively within the …
[HTML][HTML] Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms
IT Lee, AS Chang, M Manandhar, Y Shan, J Fan… - Neuron, 2015 - cell.com
Circadian behavior in mammals is orchestrated by neurons within the suprachiasmatic
nucleus (SCN), yet the neuronal population necessary for the generation of timekeeping …
nucleus (SCN), yet the neuronal population necessary for the generation of timekeeping …
[HTML][HTML] Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes
AY Elizabeth, DR Weaver - Aging (Albany NY), 2011 - ncbi.nlm.nih.gov
The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology
in virtually all cells. Disruption of the genes necessary for the circadian clock to function has …
in virtually all cells. Disruption of the genes necessary for the circadian clock to function has …