Melatonin: the placental antioxidant and anti-inflammatory

TT Joseph, V Schuch, DJ Hossack… - Frontiers in …, 2024 - frontiersin.org
Melatonin (N-acetyl-5-methoxytryptamine) is an indolamine hormone with many
physiological and biological roles. Melatonin is an antioxidant, anti-inflammatory, free …

Placentas from Women with Late-Onset Preeclampsia Exhibit Increased Expression of the NLRP3 Inflammasome Machinery

LM Garcia-Puente, O Fraile-Martinez… - Biomolecules, 2023 - mdpi.com
Pre-eclampsia is a harmful and potentially lethal medical condition during pregnancy
clinically diagnosed by hypertension and commonly accompanied by proteinuria and …

Intrauterine Growth Restriction: Need to Improve Diagnostic Accuracy and Evidence for a Key Role of Oxidative Stress in Neonatal and Long-Term Sequelae

E Nüsken, S Appel, L Saschin, C Kuiper-Makris… - Cells, 2024 - mdpi.com
Intrauterine growth restriction (IUGR) and being small for gestational age (SGA) are two
distinct conditions with different implications for short-and long-term child development. SGA …

Differential effect of lead and cadmium on mitochondrial function and NLRP3 inflammasome activation in human trophoblast

Y Dai, X Xu, X Huo, JHN Schuitemaker… - The Journal of …, 2024 - Wiley Online Library
Heavy metals disrupt mitochondrial function and activate the NOD‐like receptor pyrin‐
containing 3 (NLRP3) inflammasome. We investigated the effect of lead (Pb)/cadmium (Cd) …

Histopathological Clues of Enhanced Inflammation in the Placental Tissue of Women with Chronic Venous Disease in Lower Limbs during Pregnancy

MA Sánchez-Gil, O Fraile-Martinez… - Journal of Personalized …, 2024 - mdpi.com
It is estimated that approximately one in three women develop chronic venous disease
(CVD) during pregnancy, a broad spectrum of morphofunctional disorders affecting the …

1, 25-Dihydroxyvitamin D3 protects against placental inflammation by suppressing NLRP3-mediated IL-1β production via Nrf2 signaling pathway in preeclampsia

X Liu, X Zhang, L Ma, N Qiang, J Wang, Y Huang… - Metabolism, 2025 - Elsevier
Background Maternal vitamin D deficiency is associated with an increased risk of
preeclampsia, a potentially life-threatening multi-system disorder specific to human …

[HTML][HTML] Interleukin-6 promotes visceral adipose tissue accumulation during aging via inhibiting fat lipolysis

X Zhang, Q Wang, Y Wang, C Ma, Q Zhao, H Yin… - International …, 2024 - Elsevier
Background Age-related visceral obesity could contribute to the development of
cardiometabolic complications. The pathogenesis of visceral fat mass accumulation during …

Omega‐3 fatty acid supplements and recurrent miscarriage: A perspective on potential mechanisms and clinical evidence

F Mu, H Huo, M Wang, F Wang - Food Science & Nutrition, 2023 - Wiley Online Library
Recurrent miscarriage (RM) affects approximately 1%–5% of couples worldwide. Due to its
complicated etiologies, the treatments for RM also vary greatly, including surgery for …

NLRP7 Enhances Choriocarcinoma Cell Survival and Camouflage in an Inflammasome Independent Pathway

D Reynaud, N Alfaidy, C Collet, N Lemaitre, F Sergent… - Cells, 2023 - mdpi.com
Background: Gestational choriocarcinoma (GC) is a highly malignant trophoblastic tumor
that often develops from a complete hydatidiform mole (HM). NLRP7 is the major gene …

[HTML][HTML] Single-cell RNA sequencing reveals association of aberrant placental trophoblasts and FN1 reduction in late-onset fetal growth restriction

Q Hua, Z Li, Y Zhou, Y Wang, Y Yu, L Sun, J Ye, L Li - Placenta, 2024 - Elsevier
Introduction Fetal growth restriction (FGR) can lead to fetal mental development
abnormalities, malformations, and even intrauterine death. Defects in the trophoblasts at the …