Leishmania-based expression systems

T Taheri, N Seyed, A Mizbani, S Rafati - Applied microbiology and …, 2016 - Springer
Production of therapeutic or medical recombinant proteins, such as monoclonal antibodies,
proteins, or active enzymes, requires a highly efficient system allowing natural folding and …

Iron superoxide dismutase contributes to miltefosine resistance in Leishmania donovani

J Veronica, S Chandrasekaran, A Dayakar… - The FEBS …, 2019 - Wiley Online Library
The emergence of drug‐resistant Leishmania is the major challenge to management of
visceral leishmaniasis (VL) in areas in which this parasite is endemic. Miltefosine has been …

A novel chemically defined medium for the biotechnological and biomedical exploitation of the cell factory Leishmania tarentolae

GM Cattaneo, I Varotto-Boccazzi, R Molteni… - Scientific Reports, 2024 - nature.com
The development of media for cell culture is a major issue in the biopharmaceutical industry,
for the production of therapeutics, immune-modulating molecules and protein antigens …

Live Leishmania tarentolae Secreting HNP1 as an Immunotherapeutic Tool Against Leishmania Infection in BALB/c Mice

Z Abdossamadi, T Taheri, N Seyed… - …, 2017 - Taylor & Francis
Aim: Several disadvantages about chemotherapy for leishmaniasis has reinforced discovery
of novel therapeutic agents especially immunotherapeutics. HNP1, as a member of the …

Evaluation of CAAX prenyl protease II of Leishmania donovani as potential drug target: Infectivity and growth of the parasite is significantly lowered after the gene …

R Bhardwaj, M Das, S Singh, AK Chiranjivi… - European Journal of …, 2017 - Elsevier
Prenylation pathway is responsible for post translational modification of various signal
proteins, including proteins of Ras superfamily. CAAX prenyl proteases are known to be key …

Understanding the importance of conservative hypothetical protein LdBPK_070020 in Leishmania donovani and its role in subsistence of the parasite

R Bhardwaj, R Kumar, SK Singh, C Selvaraj… - Archives of Biochemistry …, 2016 - Elsevier
The genome of Leishmania donovani, the causative agent of visceral leishmaniasis, codes
for approximately 65% of both conserved and non-conserved hypothetical proteins. Studies …

تولید انگلهای نوترکیب لیشمانیا تروپیکا بیان کننده دو پروتئین گزارشگرEGFP و لوسیفراز

طاهری, اسکندر, رأفتی - مجله علمی دانشگاه علوم پزشکی بابل, 2017‎ - jbums.org
یارب رثؤم و عیرس یا هویش دوجو مدع نآ لیلاد زا یكی. تسا هدشن فشک تارثا، یمیدق یاهشور رد. دشاب
یم لاعف و دیدج یاهوراد یرگلابرغ و باختنا سپ، یناویح یاه لدم رد ای یلولس تشک رد اهتوگیتساما …