Discoveries in structure and physiology of mechanically activated ion channels

JM Kefauver, AB Ward, A Patapoutian - Nature, 2020 - nature.com
The ability to sense physical forces is conserved across all organisms. Cells convert
mechanical stimuli into electrical or chemical signals via mechanically activated ion …

Plant abiotic stress response and nutrient use efficiency

Z Gong, L Xiong, H Shi, S Yang… - Science China Life …, 2020 - Springer
Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce
plant growth, productivity and quality. Plants have evolved mechanisms to perceive these …

Non-invasive transcranial ultrasound stimulation for neuromodulation

G Darmani, TO Bergmann, KB Pauly, CF Caskey… - Clinical …, 2022 - Elsevier
Transcranial ultrasound stimulation (TUS) holds great potential as a tool to alter neural
circuits non-invasively in both animals and humans. In contrast to established non-invasive …

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

H Wang, JA Kulas, C Wang… - Proceedings of the …, 2021 - National Acad Sciences
Alzheimer's disease (AD) is characterized by the presence of amyloid β (Aβ) plaques, tau
tangles, inflammation, and loss of cognitive function. Genetic variation in a cholesterol …

Compositional dynamics of the milk fat globule and its role in infant development

H Lee, E Padhi, Y Hasegawa, J Larke, M Parenti… - Frontiers in …, 2018 - frontiersin.org
Human milk is uniquely optimized for the needs of the developing infant. Its composition is
complex and dynamic, driven primarily by maternal genetics, and to a lesser extent by diet …

Biophysical principles of ion-channel-mediated mechanosensory transduction

CD Cox, N Bavi, B Martinac - Cell reports, 2019 - cell.com
Recent rapid progress in the field of mechanobiology has been driven by novel emerging
tools and methodologies and growing interest from different scientific disciplines. Specific …

Ultrasound activates mechanosensitive TRAAK K+ channels through the lipid membrane

B Sorum, RA Rietmeijer… - Proceedings of the …, 2021 - National Acad Sciences
Ultrasound modulates the electrical activity of excitable cells and offers advantages over
other neuromodulatory techniques; for example, it can be noninvasively transmitted through …

The role of high cholesterol in age-related COVID19 lethality

H Wang, Z Yuan, MA Pavel, SM Jablonski… - BioRxiv, 2021 - pmc.ncbi.nlm.nih.gov
Coronavirus disease 2019 (COVID19) is a respiratory infection caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China in 2019 …

Studies on the mechanism of general anesthesia

MA Pavel, EN Petersen, H Wang… - Proceedings of the …, 2020 - National Acad Sciences
Inhaled anesthetics are a chemically diverse collection of hydrophobic molecules that
robustly activate TWIK-related K+ channels (TREK-1) and reversibly induce loss of …

Biological membrane organization and cellular signaling

X Cheng, JC Smith - Chemical reviews, 2019 - ACS Publications
To execute their many vital functions, cell membranes are highly organized. Here, we review
how membrane structure shapes signal transduction across membranes. Recent …