Spermatogenesis and folliculogenesis involve cell–cell interactions and gene expression
orchestrated by luteinizing hormone (LH) and follicle-stimulating hormone (FSH). FSH …

Spermatogenesis is a concerted sequence of events during maturation of spermatogonia
into spermatozoa. The process involves differential gene-expression and cell-cell interplay …

Sertoli cells are somatic cells present in seminiferous tubules which have essential roles in
regulating spermatogenesis. Considering that each Sertoli cell is able to support a limited …

Evaluation of testicular functions (production of sperm and androgens) is an important
aspect of preclinical safety assessment and testicular toxicity is comparatively far more …

Spermatogenesis is completely dependent on the pituitary hormone follicle-stimulating
hormone (FSH) and androgens locally produced in response to luteinising hormone (LH) …

Androgens such as testosterone are steroid hormones essential for normal male
reproductive development and function. Mutations of androgen receptors (AR) are often …

Sertoli cells regulate differentiation and development of the testis and are essential for
maintaining adult testis function. To model the effects of dysregulating Sertoli cell number …

Testosterone is essential for spermatogenesis and male fertility. In this review, topics related
to testosterone control of spermatogenesis are covered including testosterone production …

Peritubular myoid (PM) cells surround the seminiferous tubule and together with Sertoli cells
form the cellular boundary of the spermatogonial stem cell (SSC) niche. However, it remains …

Follicle-stimulating hormone signaling is essential for the initiation and early stages of
spermatogenesis. Follicle-stimulating hormone receptor is exclusively expressed in Sertoli …