Cardiac troponin I (cTnI) is a key regulatory protein in cardiac muscle contraction and
relaxation, linking Ca2+–troponin C binding with activation of crossbridge reactions with the …

▪ Abstract Although well known as the location of the mechanism by which the cardiac
sarcomere is activated by Ca2+ to generate force and shortening, the thin filament is now …

We focus here on the modulation of thin filament activity by cardiac troponin I
phosphorylation as an integral and adaptive mechanism in cardiac homeostasis and as a …

It is becoming clear that upregulated protein kinase C (PKC) signaling plays a role in
reduced ventricular myofilament contractility observed in congestive heart failure. However …

An altered cardiac myofilament response to activating Ca 2+ is a hallmark of human heart
failure. Phosphorylation of cardiac troponin I (cTnI) is critical in modulating contractility and …

We review development of evidence and current perceptions of the multiple and significant
functions of cardiac troponin I in regulation and modulation of cardiac function. Our …

The transient change in tension development and length in a working cardiac myocyte
during the heart beat reflects the integrated effects of kinases in signaling cascades …

Myocardial contraction is initiated upon the release of calcium into the cytosol from the
sarcoplasmic reticulum following membrane depolarization. The fundamental physiological …

We present here the solution structure for the bisphosphorylated form of the cardiac N-
extension of troponin I (cTnI1-32), a region for which there are no previous high-resolution …

We discuss a current controversy regarding the relative role of phosphorylation sites on
cardiac troponin I (cTnI)(Fig. 1) in physiological and patho-physiological cardiac function …