Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …

The year 2007 marks exactly two decades since Human Epidermal Growth Factor Receptor-
2 (HER2) was functionally implicated in the pathogenesis of human breast cancer. This …

Over the last two decades, a new and unifying concept of cellular organization has emerged
in which modular protein-protein interactions provide an underlying framework through …

This review article describes the pathways and mechanisms of endocytosis and post-
endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family …

Mammalian epithelial tumors lose polarity as they progress toward malignancy, but whether
polarity loss might causally contribute to cancer has remained unclear. In Drosophila …

Kekkon proteins negatively regulate the epidermal growth factor receptor (EGFR) during
oogenesis in Drosophila. Their structural relative in mammals, LRIG1, is a transmembrane …

The NF2 tumor-suppressor gene was cloned more than a decade ago, but the function of its
encoded protein, Merlin, remains elusive. Merlin, like the closely related ERM proteins …

Polarized cells establish and maintain functionally distinct surface domains by an elaborate
sorting process, which ensures accurate delivery of biosynthetic cargo to different parts of …

Despite significant improvement in modalities for treatment of cancer that led to a longer
survival period, the death rate of patients with solid tumors has not changed during the last …

The epidermal growth factor receptor (EGFR) signaling cascade represents one of the
cardinal pathways that transmits information between cells during development in a broad …