Metastasis is responsible for the greatest number of cancer deaths. Metastatic disease, or
the movement of cancer cells from one site to another, is a complex process requiring …

Rho-associated coiled-coil-containing protein kinase (ROCK)/Lin11, Isl-1 and Mec-3 kinase
(LIMK)/cofilin-signaling cascades are stimulated by receptor tyrosine kinases, G protein …

Metastasis is responsible for most cancer-related deaths, but the current clinical treatments
are not effective. Recently, gold nanoparticles (AuNPs) were discovered to inhibit cancer cell …

Compounds targeting microtubules are widely used in cancer therapy with a proven efficacy.
However, because they also target non-cancerous cells, their administration leads to …

LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) are serine/threonine and tyrosine kinases
and the only two members of the LIM kinase family. They play a crucial role in the regulation …

LIM kinases are common downstream effectors of several signalization pathways and
function as a signaling node that controls cytoskeleton dynamics through the …

Understanding how cells integrate multiple signaling pathways to achieve specific cell
differentiation is a challenging question in cell biology. We have explored the physiological …

Blood platelets are anuclear cell fragments that are essential for blood clotting. Platelets are
produced by bone marrow megakaryocytes (MKs), which extend protrusions, or so-called …

Multidrug resistance and radioresistance are major obstacles for successful cancer therapy.
Due to the unique characteristics of high surface area, improved cellular uptake, and the …

Abstract Aims: The RhoA/ROCK pathway controls crucial biological processes involved in
cardiovascular pathophysiology, such as cytoskeleton dynamics, vascular smooth muscle …