Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation

H Nguyen, HL Nguyen, PD Lan, NQ Thai… - Chemical Society …, 2023 - pubs.rsc.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

Structure and dynamics of membrane proteins by magic angle spinning solid-state NMR

A McDermott - Annual review of biophysics, 2009 - annualreviews.org
Membrane proteins remain difficult to study by traditional methods. Magic angle spinning
solid-state NMR (MAS SSNMR) methods present an important approach for studying …

Molecular-Level Examination of Cu2+ Binding Structure for Amyloid Fibrils of 40-Residue Alzheimer's β by Solid-State NMR Spectroscopy

S Parthasarathy, F Long, Y Miller, Y Xiao… - Journal of the …, 2011 - ACS Publications
Cu2+ binding to Alzheimer's β (Aβ) peptides in amyloid fibrils has attracted broad attention,
as it was shown that Cu ion concentration elevates in Alzheimer's senile plaque and such …

Broadband homonuclear correlation spectroscopy driven by combined R2nv sequences under fast magic angle spinning for NMR structural analysis of organic and …

G Hou, S Yan, J Trebosc, JP Amoureux… - Journal of Magnetic …, 2013 - Elsevier
We recently described a family of experiments for R2nv Driven Spin Diffusion (RDSD)
spectroscopy suitable for homonuclear correlation experiments under fast MAS conditions …

Fusion activity of HIV gp41 fusion domain is related to its secondary structure and depth of membrane insertion in a cholesterol-dependent fashion

AL Lai, AE Moorthy, Y Li, LK Tamm - Journal of molecular biology, 2012 - Elsevier
The human immunodeficiency virus (HIV) gp41 fusion domain plays a critical role in
membrane fusion during viral entry. A thorough understanding of the relationship between …

The three lives of viral fusion peptides

B Apellániz, N Huarte, E Largo, JL Nieva - Chemistry and physics of lipids, 2014 - Elsevier
Fusion peptides comprise conserved hydrophobic domains absolutely required for the
fusogenic activity of glycoproteins from divergent virus families. After 30 years of intensive …

Membrane composition modulates fusion by altering membrane properties and fusion peptide structure

G Meher, H Chakraborty - The Journal of membrane biology, 2019 - Springer
Membrane fusion, one of the most essential processes in the life of eukaryotes, occurs when
two separate lipid bilayers merge into a continuous bilayer and internal contents of two …

A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion

P Guardado-Calvo, K Atkovska, SA Jeffers, N Grau… - Science, 2017 - science.org
The Rift Valley fever virus (RVFV) is transmitted by infected mosquitoes, causing severe
disease in humans and livestock across Africa. We determined the x-ray structure of the …

Mechanistic insights of host cell fusion of SARS-CoV-1 and SARS-CoV-2 from atomic resolution structure and membrane dynamics

H Chakraborty, S Bhattacharjya - Biophysical Chemistry, 2020 - Elsevier
The emerging and re-emerging viral diseases are continuous threats to the wellbeing of
human life. Previous outbreaks of Severe Acute Respiratory Syndrome (SARS) and Middle …

A strong correlation between fusogenicity and membrane insertion depth of the HIV fusion peptide

W Qiang, Y Sun, DP Weliky - Proceedings of the National …, 2009 - National Acad Sciences
Fusion between the membrane of HIV and the membrane of a host cell is a crucial step in
HIV infection and is catalyzed by the binding of the fusion peptide domain (HFP) of the HIV …