Simple Summary Acquired resistance to chemotherapy by cancer cells is the predominant
factor in chemotherapy failure, which ultimately leads to disease progression and death …

Despite the recent advances in chemotherapeutic treatments against cancer, some types of
highly aggressive and invasive cancer develop drug resistance against conventional …

DNA methylation is an epigenetic alteration that results in 5-methylcytosine (5-mC) through
the addition of a methyl group to the fifth carbon of a cytosine (C) residue. The methylation …

Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …

Abstract Treatment with 5-fluorouracil (5-FU) based therapy is still used for colorectal cancer
(CRC). Epigenetics has become a focus of study in cancer because of its reversibility …

Genetic and epigenetic modifications of genes involved in the key regulatory pathways play
a significant role in the pathophysiology and progression of multifactorial diseases. The …

Personalized drug therapy aims to provide tailored treatment for individual patient. Mass
spectrometry (MS) is revolutionarily involved in this area because MS is a rapid …

Background Methylation of cytosine residues resulting in 5-methylcytosine (5-mC) is an
important epigenetic modification associated with tumorigenesis. The present study …

Introduction: Screening methods for one of the most frequently diagnosed malignancy,
colorectal cancer (CRC), have limitations. Circulating cell-free nucleic acids (cfNA) hold …

Background RNA modification has become one of the hot topics of research as it can be
used for tumor prognosis. However, its role in various biological processes is still poorly …