FOXO3a is a member of the FOXO subfamily of forkhead transcription factors that mediate a
variety of cellular processes including apoptosis, proliferation, cell cycle progression, DNA …

Anaplastic thyroid cancer (ATC) is an extremely aggressive but rare form of thyroid
malignancy, making up only 1% to 2% of all thyroid cancers. 1 Although the incidence of …

Cancer progression involves multiple genetic and epigenetic events, which involve gain-of-
functions of oncogenes and loss-of-functions of tumor suppressor genes. Classical tumor …

Forkhead transcription factor FoxO3a has been reported to have ambiguous functions and
distinct mechanisms in various solid tumors, including glioblastoma (GBM). Although a …

Disease gene prediction is a challenging task that has a variety of applications such as early
diagnosis and drug development. The existing machine learning methods suffer from the …

Background Cyclin A1 is essential for male gametopoiesis. In acute myeloid leukemia, it acts
as a leukemia-associated antigen. Cyclin A1 expression has been reported in several …

Autophagy is a highly conserved intracellular degradation process that plays a crucial role in
cell survival and stress reactions as well as in cancer development and metastasis …

Patients with chronic obstructive pulmonary disease (COPD) who are defined as frequent
exacerbators suffer with 2 or more exacerbations every year. The molecular mechanisms …

Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies that currently
has no effective therapy. We performed quantitative high-throughput screening (qHTS) in …

Industrialisation, the proximity of factories to cities, and human work activities have led to a
disproportionate use of substances containing heavy metals, such as cadmium (Cd), which …