Interferons (IFNs) constitute the first line of defense against microbial infections particularly
against viruses. They provide antiviral properties to cells by inducing the expression of …

The anti‐inflammatory master regulator IL‐10 is critical to protect the host from tissue
damage during acute phases of immune responses. This regulatory mechanism, central to T …

The IL-10 family of cytokines consists of nine members: IL-10, IL-19, IL-20, IL-22, IL-24, IL-
26, and the more distantly related IL-28A, IL-28B, and IL-29. Evolutionarily, IL-10 family …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

Interleukin (IL)-10 is the most important cytokine with anti-inflammatory properties besides
TGF-β and IL-35. It is produced by activated immune cells, in particular monocytes …

Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …

Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine and functions as a
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …

Herein we report the generation of mice lacking the ubiquitously expressed Janus kinase,
Jak1. Jak1−/− mice are runted at birth, fail to nurse, and die perinatally. Although Jak1 …

Many cell functions are regulated by members of the cytokine receptor superfamily.
Signalling by these receptors depends upon their association with Janus kinases (JAKs) …

Publisher Summary This chapter summarizes the recent knowledge on the production of
cytokines by neutrophils in vitro and in vivo—particularly molecular regulation and other …