The goal here is to describe our current understanding of heme metabolism and the
deleterious effects of “free” heme on immunological processes, endothelial function …

Sepsis and trauma are both leading causes of death in the United States and represent
major public health challenges. Murine models have largely been used in sepsis and …

Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers
of COVID-19 patients all over the world. Clinical presentations range from asymptomatic …

Improved risk stratification and prognosis prediction in sepsis is a critical unmet need.
Clinical severity scores and available assays such as blood lactate reflect global illness …

Acute respiratory infections caused by bacterial or viral pathogens are among the most
common reasons for seeking medical care. Despite improvements in pathogen-based …

Intensive care unit (ICU) practitioners and emergency department clinicians are in urgent
need of a major upgrade in their access to accurate and fast microbial diagnosis (Table 1) …

Rationale: A molecular test to distinguish between sepsis and systemic inflammation of
noninfectious etiology could potentially have clinical utility. Objectives: This study evaluated …

Systemic inflammation is established as part of late-stage severe lung disease, but
molecular, functional, and phenotypic changes in peripheral immune cells in early disease …

Objectives Immunological dysregulation is now recognised as a major pathogenic event in
sepsis. Stimulation of immune response and immuno-modulation are emerging approaches …

Recent clinical and research efforts in cardiogenic shock (CS) have largely focussed on the
restoration of the low cardiac output state that is the conditio sine qua non of the clinical …