Guidelines for experimental models of myocardial ischemia and infarction

ML Lindsey, R Bolli, JM Canty Jr… - American Journal …, 2018 - journals.physiology.org
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …

[HTML][HTML] Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments

VC Henderson, J Kimmelman, D Fergusson… - PLoS …, 2013 - journals.plos.org
Background The vast majority of medical interventions introduced into clinical development
prove unsafe or ineffective. One prominent explanation for the dismal success rate is flawed …

[HTML][HTML] Experimental design and analysis and their reporting: new guidance for publication in BJP

MJ Curtis, RA Bond, D Spina, A Ahluwalia… - British journal of …, 2015 - ncbi.nlm.nih.gov
This editorial is part of a series describing changes in the guidelines for authors making
submissions to the British Journal of Pharmacology (BJP)(McGrath and Curtis, 2015); …

[HTML][HTML] Neutrophils incite and macrophages avert electrical storm after myocardial infarction

J Grune, AJM Lewis, M Yamazoe… - Nature cardiovascular …, 2022 - nature.com
Sudden cardiac death, arising from abnormal electrical conduction, occurs frequently in
patients with coronary heart disease. Myocardial ischemia simultaneously induces …

[HTML][HTML] Acute dapagliflozin administration exerts cardioprotective effects in rats with cardiac ischemia/reperfusion injury

S Lahnwong, S Palee, N Apaijai, S Sriwichaiin… - Cardiovascular …, 2020 - Springer
Background A sodium-glucose co-transporter 2 (SGLT-2) inhibitor had favorable impact on
the attenuation of hyperglycemia together with the severity of heart failure. However, the …

[HTML][HTML] A comparative review on heart ion channels, action potentials and electrocardiogram in rodents and human: extrapolation of experimental insights to clinic

S Joukar - Laboratory Animal Research, 2021 - Springer
Electrocardiogram (ECG) is a non-invasive valuable diagnostic tool that is used in clinics for
investigation and monitoring of heart electrical rhythm/conduction, ischemia/injury of heart …

Anticancer drug-induced cardiac rhythm disorders: current knowledge and basic underlying mechanisms

J Alexandre, JJ Moslehi, KR Bersell… - Pharmacology & …, 2018 - Elsevier
Significant advances in cancer treatment have resulted in decreased cancer related
mortality for many malignancies with some cancer types now considered chronic diseases …

Gene Therapy for Catecholaminergic Polymorphic Ventricular Tachycardia by Inhibition of Ca2+/Calmodulin-Dependent Kinase II

VJ Bezzerides, A Caballero, S Wang, Y Ai, RJ Hylind… - Circulation, 2019 - Am Heart Assoc
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited
cardiac arrhythmia characterized by adrenergically triggered arrhythmias, is inadequately …

Misinterpretation of the mouse ECG: 'musing the waves of Mus musculus'

BJ Boukens, MR Rivaud, S Rentschler… - The Journal of …, 2014 - Wiley Online Library
The ECG is a primary diagnostic tool in patients suffering from heart disease, underscoring
the importance of understanding factors contributing to normal and abnormal electrical …

[HTML][HTML] Cardioprotection of dapagliflozin and vildagliptin in rats with cardiac ischemia-reperfusion injury

P Tanajak, P Sa-Nguanmoo… - Journal of …, 2018 - joe.bioscientifica.com
Sodium-glucose cotransporter 2 inhibitor (SGLT2-i) effects on cardiac ischemia/reperfusion
(I/R) injury are unclear. Unlike SGLT2-i, dipeptidyl peptidase 4 inhibitors (DPP4-i) have …