In-line fluidic devices and mills are often used for controlling crystal size distribution during
crystallization. In this work, we investigated the breakage of organic crystals in three particle …

Obtaining a particle size within the specifications for a pharmaceutical compound in an
industrial crystallization can be a challenging task. The events affecting the final particle size …

Metastable polymorphic pharmaceuticals have garnered significant attention in recent years
due to their enhanced physicochemical properties, including solubility, bioavailability, and …

Selective crystallization of a pure product from complex mixtures is challenging due to the
variety of impurities which can potentially affect the crystallization process and hence …

As an important pharmaceutical process, crystallization greatly impacts the final product. In
recent years, the continuous crystallization process has attracted more attention from …

Automation plays a vital role in reducing development time in the pharmaceutical industry,
both for drug substance (DS) and drug product (DP). Many aspects of crystallization …

Continuous crystallization has gained substantial interest due to its high product
reproducibility, high labor efficiency, and low capital and production costs. Continuous …

Continuous crystallization provides advantages of producing solid products of consistent
quality attributes at a small equipment footprint. However, the intrinsic nucleation and growth …

Continuous mixed-suspension mixed-product removal crystallizer cascades are robust and
proven options for continuous manufacturing. However, when applied to a late-stage drug …

Selective product crystallization for separation and recycling of homogeneous catalysts
represents one novel promising method to develop sustainable chemical processes. This …