Graft-versus-host disease
Haemopoietic-cell transplantation (HCT) is an intensive therapy used to treat high-risk
haematological malignant disorders and other life-threatening haematological and genetic …
haematological malignant disorders and other life-threatening haematological and genetic …
T cell subsets in graft versus host disease and graft versus tumor
Allogeneic hematopoietic cell transplantation (allo-HCT) is an essential therapeutic modality
for patients with hematological malignancies and other blood disorders. Unfortunately, acute …
for patients with hematological malignancies and other blood disorders. Unfortunately, acute …
Gut microbiome–derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease
ND Mathewson, R Jenq, AV Mathew… - Nature …, 2016 - nature.com
The effect of alterations in intestinal microbiota on microbial metabolites and on disease
processes such as graft-versus-host disease (GVHD) is not known. Here we carried out an …
processes such as graft-versus-host disease (GVHD) is not known. Here we carried out an …
HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse
MF Martelli, M Di Ianni, L Ruggeri… - Blood, The Journal …, 2014 - ashpublications.org
Posttransplant relapse is still the major cause of treatment failure in high-risk acute
leukemia. Attempts to manipulate alloreactive T cells to spare normal cells while killing …
leukemia. Attempts to manipulate alloreactive T cells to spare normal cells while killing …
Outcomes of allogeneic haematopoietic stem cell transplantation from HLA-matched and alternative donors: a European Society for Blood and Marrow …
Background The introduction of donors other than HLA-matched siblings has been a pivotal
change in stem cell transplantation. We aimed to assess the evolution of outcomes within …
change in stem cell transplantation. We aimed to assess the evolution of outcomes within …
Immunobiology of allogeneic hematopoietic stem cell transplantation
Allogeneic hematopoietic stem cell transplantation (HSCT) has evolved into an effective
adoptive cellular immunotherapy for the treatment of a number of cancers. The …
adoptive cellular immunotherapy for the treatment of a number of cancers. The …
Dendritic cell homeostasis
M Merad, MG Manz - Blood, The Journal of the American …, 2009 - ashpublications.org
Dendritic cells (DCs) are a heterogeneous fraction of rare hematopoietic cells that coevolved
with the formation of the adaptive immune system. DCs efficiently process and present …
with the formation of the adaptive immune system. DCs efficiently process and present …
The biology of graft-versus-host disease: experimental systems instructing clinical practice
KA Markey, KPA MacDonald… - Blood, The Journal of the …, 2014 - ashpublications.org
The last 6 decades have seen major advances in the understanding of immunologic
diseases, driven by preclinical animal models. Indeed, bone marrow transplantation (BMT) …
diseases, driven by preclinical animal models. Indeed, bone marrow transplantation (BMT) …
Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) was the first successful
therapy for patients with haematological malignancies, predominantly owing to graft-versus …
therapy for patients with haematological malignancies, predominantly owing to graft-versus …
Microbial metabolite sensor GPR43 controls severity of experimental GVHD
Microbiome-derived metabolites influence intestinal homeostasis and regulate graft-versus-
host disease (GVHD), but the molecular mechanisms remain unknown. Here we show the …
host disease (GVHD), but the molecular mechanisms remain unknown. Here we show the …