Towards a youth mental health paradigm: a perspective and roadmap

PJ Uhlhaas, CG Davey, UM Mehta, J Shah… - Molecular …, 2023 - nature.com
Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …

[HTML][HTML] Microglia and beyond: innate immune cells as regulators of brain development and behavioral function

KM Lenz, LH Nelson - Frontiers in immunology, 2018 - frontiersin.org
Innate immune cells play a well-documented role in the etiology and disease course of
many brain-based conditions, including multiple sclerosis, Alzheimer's disease, traumatic …

[HTML][HTML] Shared and unique brain network features predict cognitive, personality, and mental health scores in the ABCD study

J Chen, A Tam, V Kebets, C Orban, LQR Ooi… - Nature …, 2022 - nature.com
How individual differences in brain network organization track behavioral variability is a
fundamental question in systems neuroscience. Recent work suggests that resting-state and …

Biological aging in childhood and adolescence following experiences of threat and deprivation: A systematic review and meta-analysis.

NL Colich, ML Rosen, ES Williams… - Psychological …, 2020 - psycnet.apa.org
Life history theory argues that exposure to early life adversity (ELA) accelerates
development, although existing evidence for this varies. We present a meta-analysis and …

Association of structural magnetic resonance imaging measures with psychosis onset in individuals at clinical high risk for developing psychosis: an ENIGMA working …

M Jalbrzikowski, RA Hayes, SJ Wood… - JAMA …, 2021 - jamanetwork.com
Importance The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled
neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological …

Graph theory approaches to functional network organization in brain disorders: A critique for a brave new small-world

MN Hallquist, FG Hillary - Network neuroscience, 2018 - direct.mit.edu
Over the past two decades, resting-state functional connectivity (RSFC) methods have
provided new insights into the network organization of the human brain. Studies of brain …

Development of frontal GABA and glutamate supports excitation/inhibition balance from adolescence into adulthood

MI Perica, FJ Calabro, B Larsen, W Foran… - Progress in …, 2022 - Elsevier
Animal and human postmortem studies provide evidence for changes in gamma-
aminobutyric acid (GABA) and glutamate in prefrontal cortex (PFC) during adolescence …

Neural substrates of inhibitory control maturation in adolescence

C Constantinidis, B Luna - Trends in neurosciences, 2019 - cell.com
Inhibitory control matures through adolescence and into early adulthood, impacting decision-
making. Impairments in inhibitory control are associated with various psychopathologies …

[HTML][HTML] Early social adversity, altered brain functional connectivity, and mental health

NE Holz, O Berhe, S Sacu, E Schwarz, J Tesarz… - Biological …, 2023 - Elsevier
Early adverse environmental exposures during brain development are widespread risk
factors for the onset of severe mental disorders and strong and consistent predictors of …

[HTML][HTML] Leveraging multi-shell diffusion for studies of brain development in youth and young adulthood

AR Pines, M Cieslak, B Larsen, GL Baum… - Developmental cognitive …, 2020 - Elsevier
Diffusion weighted imaging (DWI) has advanced our understanding of brain microstructure
evolution over development. Recently, the use of multi-shell diffusion imaging sequences …