Summary The Chimeric Antigen Receptor (CAR) T cell therapy has emerged as a ground-
breaking immunotherapeutic approach in cancer treatment. To overcome the complexity and …

Biomedical polymers play a key role in preventing, diagnosing, and treating diseases,
showcasing a wide range of applications. Their unique advantages, such as rich source …

Gene therapy involves the introduction of exogenous genetic material into host tissues to
modify gene expression or cellular properties for therapeutic purposes. Initially developed to …

Non-viral vectors for mRNA delivery primarily include lipid nanoparticles (LNPs) and
polymers. While LNPs are known for their high mRNA delivery efficiency, they can induce …

The successful use of mRNA vaccines enabled and accelerated the development of several
new vaccine candidates and therapeutics based on the delivery of mRNA. In this study, we …

Immunotherapy has emerged as a promising approach to cancer treatment, offering
improved survival rates and enhanced patients' quality of life. However, realizing the full …

Abstract Poly (β‐amino ester)(PBAE) is a class of biodegradable polymers containing ester
bonds in their main chain, extensively investigated as cationic polymer carriers for siRNA …

mRNA-based therapies hold tremendous promise for treating various diseases, yet their
clinical success is hindered by delivery challenges. This study developed a library of 140 …

Successful therapeutic delivery of siRNA with polymeric nanoparticles seems to be a
promising but not vastly understood and complicated goal to achieve. Despite years of …

Highlights•Block copolymer-based nanomedicine has emerged as an intriguing class of
therapeutic materials.•Owing to their outstanding characteristics block copolymers have …