Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …

The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the
emergence of challenging variants has created an urgent need of alternative therapeutic …

Drug repositioning is an important component of therapeutic stratification in the precision
medicine paradigm. Molecular profiling and more sophisticated analysis of longitudinal …

Cholangiocarcinoma (CCA) presents a formidable therapeutic challenge due to its extensive
heterogeneity and plasticity, which inevitably lead to acquired resistance to current …

Influenza A virus (IAV) infection causes seasonal epidemics of contagious respiratory illness
that causes substantial morbidity and some mortality. Regular vaccination is the principal …

RNA viruses like SARS-CoV-2, influenza virus, and respiratory syncytial virus (RSV) are
dependent on host genes for replication. We investigated if probenecid, an FDA-approved …

Influenza can cause respiratory infections, leading to significant morbidity and mortality in
humans. While current influenza vaccines offer varying levels of protection, there remains a …

Genetics has recently benefited from the genome engineering revolution: genes can be
knocked out, knocked down, or activated more easily than ever before. This range of genetic …

Drug discovery and development is a time consuming, costly and risky venture. As an
alternative approach, pharmaceutical companies have adopted drug repositioning (also …

Human metapneumovirus (HMPV) is an important cause of acute respiratory tract infection
and causes significant morbidity and mortality. There is no specific antiviral drug to treat …