In the lungs, macrophages constitute the first line of defense against pathogens and foreign
bodies and play a fundamental role in maintaining tissue homeostasis. Activated …

Endogenous small molecules are metabolic regulators of cell function. Itaconate is a key
molecule that accumulates in cells when the Krebs cycle is disrupted. Itaconate is derived …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …

Sepsis is a challenging clinical syndrome caused by a dysregulated host response to
infection. Here, we identified an unexpected proseptic activity of aconitate decarboxylase 1 …

Carboplatin is the most used first-line drug for the treatment of human retinoblastoma (RB), a
rare form of cancer in infancy and childhood. However, the clinical application of carboplatin …

Background Dexamethasone improves the survival of COVID-19 patients in need of
supplemental oxygen therapy. Although its broad immunosuppressive effects are well …

Metabolites have recently been found to be involved in significant biological regulation and
changes. Itaconate, an important intermediate metabolite isolated from the tricarboxylic acid …

Probiotic supplements are potential therapeutic agents for age-related cognitive deficits. A
prior study showed that probiotic Lactobacillus paracasei PS23 (PS23) supplementation …

Defects in mitochondrial oxidative phosphorylation (OXPHOS) have been reported in COVID-
19 patients, but the timing and organs affected vary among reports. Here, we reveal the …

Inflammation plays a central role in immune response and macrophage activation. Emerging
studies demonstrate that along with proteins and genomic factors, noncoding RNA are …