A knowledge graph to interpret clinical proteomics data

A Santos, AR Colaço, AB Nielsen, L Niu… - Nature …, 2022 - nature.com
Implementing precision medicine hinges on the integration of omics data, such as
proteomics, into the clinical decision-making process, but the quantity and diversity of …

AIM/CD5L: a key protein in the control of immune homeostasis and inflammatory disease

L Sanjurjo, G Aran, N Roher… - Journal of Leucocyte …, 2015 - academic.oup.com
CD5L, a soluble protein belonging to the SRCR superfamily, is expressed mostly by
macrophages in lymphoid and inflamed tissues. The expression of this protein is …

Clinical impact of alcohol‐related cirrhosis in the next decade: estimates based on current epidemiological trends in the United States

J Guirguis, J Chhatwal, J Dasarathy… - Alcoholism: Clinical …, 2015 - Wiley Online Library
Background Identifying changes in the epidemiology of liver disease is critical for
establishing healthcare priorities and allocating resources to develop therapies. The …

The human CD5L/AIM-CD36 axis: a novel autophagy inducer in macrophages that modulates inflammatory responses

L Sanjurjo, N Amézaga, G Aran, M Naranjo-Gómez… - Autophagy, 2015 - Taylor & Francis
CD5L (CD5 molecule-like) is a secreted glycoprotein that participates in host response to
bacterial infection. CD5L influences the monocyte inflammatory response to the bacterial …

Clinical knowledge graph integrates proteomics data into clinical decision-making

A Santos, AR Colaço, AB Nielsen, L Niu, PE Geyer… - bioRxiv, 2020 - biorxiv.org
The promise of precision medicine is to deliver personalized treatment based on the unique
physiology of each patient. This concept was fueled by the genomic revolution, but it is now …

CD5L is upregulated in hepatocellular carcinoma and promotes liver cancer cell proliferation and antiapoptotic responses by binding to HSPA5 (GRP78)

G Aran, L Sanjurjo, C Barcena… - The FASEB …, 2018 - Wiley Online Library
CD5‐like (CD5L) is a soluble scavenger cysteine‐rich protein that modulates inflammatory
responses. We studied the involvement of CD5L in liver cancer. Immunohistochemistry (IHC) …

The metabolic fingerprints of HCV and HBV infections studied by Nuclear Magnetic Resonance Spectroscopy

G Meoni, S Lorini, M Monti, F Madia, G Corti… - Scientific Reports, 2019 - nature.com
Few studies are available on metabolic changes in liver injuries and this is the first
metabolomic study evaluating a group of HCV-positive patients, before and after viral …

CD5L is a pleiotropic player in liver fibrosis controlling damage, fibrosis and immune cell content

C Bárcena, G Aran, L Perea, L Sanjurjo, É Téllez… - …, 2019 - thelancet.com
Background Chronic hepatic inflammation leads to liver fibrosis, which may progress to
cirrhosis, a condition with high morbidity. Our aim was to assess the as yet unknown role of …

[HTML][HTML] Evaluation of liver cirrhosis and hepatocellular carcinoma using Protein-Protein Interaction Networks

MJE Ardakani, A Safaei, AA Oskouie… - … and Hepatology from …, 2016 - ncbi.nlm.nih.gov
Aim: In the current study, we analysised only the articles that investigate serum proteome
profile of cirrhosis patients or HCC patients versus healthy controls. Background: Increased …

Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma

J Zhang, Y Chen, J Lin, R Jia, T An, T Dong… - DNA and Cell …, 2020 - liebertpub.com
Hepatocellular carcinoma (HCC), the sixth most common malignancy worldwide, is
characterized by a dismal prognosis due to high recurrence and metastasis rates. Thus, the …