Cell polarity changes in cancer initiation and progression

F Peglion, S Etienne-Manneville - Journal of Cell Biology, 2023 - rupress.org
Cell polarity, which consists of the morphological, structural, and functional organization of
cells along a defined axis, is a feature of healthy cells and tissues. In contrast, abnormal …

Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance

D Vitale, S Kumar Katakam, B Greve, B Jang… - The FEBS …, 2019 - Wiley Online Library
In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (CSC; or
tumor‐initiating cells) is characterized by self‐renewal, unlimited proliferative potential …

[HTML][HTML] Oligodendrogenesis and myelination regulate cortical development, plasticity and circuit function

JL Fletcher, K Makowiecki, CL Cullen… - Seminars in cell & …, 2021 - Elsevier
During cortical development and throughout adulthood, oligodendrocytes add myelin
internodes to glutamatergic projection neurons and GABAergic inhibitory neurons. In …

[HTML][HTML] Asymmetric cell division promotes therapeutic resistance in glioblastoma stem cells

M Hitomi, AP Chumakova, DJ Silver, AM Knudsen… - JCI insight, 2021 - ncbi.nlm.nih.gov
Asymmetric cell division (ACD) enables the maintenance of a stem cell population while
simultaneously generating differentiated progeny. Cancer stem cells (CSCs) undergo …

Lysosomal functions in glia associated with neurodegeneration

C Kreher, J Favret, M Maulik, D Shin - Biomolecules, 2021 - mdpi.com
Lysosomes are cellular organelles that contain various acidic digestive enzymes. Despite
their small size, they have multiple functions. Lysosomes remove or recycle unnecessary …

[HTML][HTML] Mechanisms of melanocyte polarity and differentiation: What can we learn from other neuroectoderm-derived lineages?

M Li, SK Knapp, S Iden - Current Opinion in Cell Biology, 2020 - Elsevier
Melanocytes are neuroectoderm-derived pigment-producing cells with highly polarized
dendritic morphology. They protect the skin against ultraviolet radiation by providing melanin …

The scaffolding protein DLG5 promotes glioblastoma growth by controlling Sonic Hedgehog signaling in tumor stem cells

S Kundu, MS Nandhu, SL Longo, JA Longo… - Neuro …, 2022 - academic.oup.com
Background Tumor invasion, a hallmark of malignant gliomas, involves reorganization of cell
polarity and changes in the expression and distribution of scaffolding proteins associated …

[HTML][HTML] Disrupting mechanical homeostasis promotes matrix metalloproteinase-13 mediated processing of neuron glial antigen 2 in mandibular condylar cartilage

MB Varzaneh, Y Zhao, J Rozynek, M Han… - European cells & …, 2023 - ncbi.nlm.nih.gov
Post-traumatic osteoarthritis in the temporomandibular joint (TMJ OA) is associated
dysfunctional cell-matrix mediated signalling resulting from changes in the pericellular …

LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland

R Ma, D Gong, H You, C Xu, Y Lu, G Bergers, Z Werb… - Cell reports, 2022 - cell.com
Branching morphogenesis is a fundamental process by which organs in invertebrates and
vertebrates form branches to expand their surface areas. The current dogma holds that …

Brain‐specific functions of the endocytic machinery

S Camblor‐Perujo, NL Kononenko - The FEBS Journal, 2022 - Wiley Online Library
Endocytosis is an essential cellular process required for multiple physiological functions,
including communication with the extracellular environment, nutrient uptake, and signaling …