New Findings What is the topic of this review? Pain in infancy. What advances does it
highlight? New neurophysiological research on pain processing in the human infant brain …

This review addresses the fundamental question of how we first experience pain, at the
beginning of our lives. The brain is activated by peripheral tissue damaging stimulation from …

Background Infant pain has immediate and long-term effects but is undertreated because of
a paucity of evidence-based analgesics. Although morphine is often used to sedate …

A subclass of C fibre sensory neurons found in hairy skin are activated by gentle touch [1]
and respond optimally to stroking at∼ 1–10 cm/s, serving a protective function by promoting …

Pain in infants is undertreated and poorly understood, representing a major clinical problem.
In part, this is due to our inability to objectively measure pain in nonverbal populations. We …

Immune function and sensitivity to pain are closely related, but the association between
early life inflammation and sensory nervous system development is poorly understood …

Very preterm infants may manifest neurodevelopmental impairments, even in the absence of
brain lesions. Pathogenesis is complex and multifactorial. Evidence suggests a role of early …

Newborn infants display strong nociceptive behavior in response to tissue damaging stimuli,
and this is accompanied by nociceptive activity generated in subcortical and cortical areas of …

Abstract Background/Goal Assessment and treatment of neonatal pain is difficult because
current scales are rarely validated against brain-based evidence. We sought to …

Background In the absence of verbal communication, it is challenging to infer an individual's
sensory and emotional experience. In communicative adults, functional MRI (fMRI) has been …