Regulation of cellular and systemic sphingolipid homeostasis
One hundred and fifty years ago, Johann Thudichum described sphingolipids as unusual
“Sphinx-like” lipids from the brain. Today, we know that thousands of sphingolipid molecules …
“Sphinx-like” lipids from the brain. Today, we know that thousands of sphingolipid molecules …
Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors
DJ Foster, K Dunnavant, CW Shrader… - Journal of Medicinal …, 2024 - ACS Publications
Targeting the S1P pathway has resulted in the development of S1P1 receptor modulators for
the treatment of multiple sclerosis and ulcerative colitis. We hypothesize that targeting an …
the treatment of multiple sclerosis and ulcerative colitis. We hypothesize that targeting an …
Rapid determination of sphingosine 1-phosphate association with carrier molecules by flow-induced dispersion analysis to predict sepsis outcome
I Seidita, A Ziegler, A Qalaj, MS Winkler, A Nierhaus… - iScience, 2024 - cell.com
Flow-induced dispersion analysis (FIDA) was used to investigate the association of
fluorescein isothiocyanate-labeled signaling lipid sphingosine 1-phosphate (S1P) with its …
fluorescein isothiocyanate-labeled signaling lipid sphingosine 1-phosphate (S1P) with its …
Sphingolipids as modulators of T cell function
PC de Casas - 2024 - search.proquest.com
The immune system is responsible for the preservation of homeostasis whenever a given
organism is exposed to distinct kinds of perturbations. Given the complexity of certain …
organism is exposed to distinct kinds of perturbations. Given the complexity of certain …