Metabolic reprogramming in glioma
M Strickland, EA Stoll - Frontiers in cell and developmental biology, 2017 - frontiersin.org
Many cancers have long been thought to primarily metabolize glucose for energy production—
a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the …
a phenomenon known as the Warburg Effect, after the classic studies of Otto Warburg in the …
AMPK and mTOR in cellular energy homeostasis and drug targets
The mammalian target of rapamycin (mTOR) is a central controller of cell growth and
proliferation. mTOR forms two distinct complexes, mTOR complex 1 (mTORC1) and mTOR …
proliferation. mTOR forms two distinct complexes, mTOR complex 1 (mTORC1) and mTOR …
The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases
A Hasanvand - Inflammopharmacology, 2022 - Springer
Metformin can suppress gluconeogenesis and reduce blood sugar by activating adenosine
monophosphate-activated protein kinase (AMPK) and inducing small heterodimer partner …
monophosphate-activated protein kinase (AMPK) and inducing small heterodimer partner …
AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway
T Sanli, GR Steinberg, G Singh… - Cancer biology & …, 2014 - Taylor & Francis
AMP-activated protein kinase (AMPK), an established metabolic stress sensor, has gained
popularity in cancer biology due to its ability to control cellular growth and mediate cell cycle …
popularity in cancer biology due to its ability to control cellular growth and mediate cell cycle …
[HTML][HTML] Metformin; an old antidiabetic drug with new potentials in bone disorders
The prevalence of diabetes mellitus especially type 2 diabetes mellitus is increasing all over
the world. In addition to cardiomyopathy and nephropathy, diabetics are at higher risk of …
the world. In addition to cardiomyopathy and nephropathy, diabetics are at higher risk of …
AMPK functions as an adenylate charge-regulated protein kinase
The energy sensor AMP-activated protein kinase (AMPK) is activated by metabolic stress
and restores ATP levels in cells by switching off anabolic and switching on catabolic …
and restores ATP levels in cells by switching off anabolic and switching on catabolic …
Metformin induces osteoblast differentiation via orphan nuclear receptor SHP-mediated transactivation of Runx2
WG Jang, EJ Kim, IH Bae, KN Lee, YD Kim, DK Kim… - Bone, 2011 - Elsevier
Metformin is an oral anti-diabetic drug of the biguanide class that is commonly used to treat
type 2 diabetes mellitus. This study examined the molecular mechanism for the action of …
type 2 diabetes mellitus. This study examined the molecular mechanism for the action of …
AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass
Adenosine 5′-monophosphate-activated protein kinase (AMPK), a regulator of energy
homeostasis, has a central role in mediating the appetite-modulating and metabolic effects …
homeostasis, has a central role in mediating the appetite-modulating and metabolic effects …
The crucial mechanism and therapeutic implication of RNA methylation in bone pathophysiology
C Yang, Z Dong, Z Ling, Y Chen - Ageing research reviews, 2022 - Elsevier
Methylation is the most common posttranscriptional modification in cellular RNAs, which has
been reported to modulate the alteration of RNA structure for initiating relevant functions …
been reported to modulate the alteration of RNA structure for initiating relevant functions …
Role of the energy sensor AMP-activated protein kinase in renal physiology and disease
KR Hallows, PF Mount… - American Journal of …, 2010 - journals.physiology.org
The ultrasensitive energy sensor AMP-activated protein kinase (AMPK) orchestrates the
regulation of energy-generating and energy-consuming pathways. AMPK is highly …
regulation of energy-generating and energy-consuming pathways. AMPK is highly …