The effects of extracellular vesicles and their cargo on metabolism and its adaptation to physical exercise in insulin resistance and type 2 diabetes

L Mastrototaro, M Roden - Proteomics, 2024 - Wiley Online Library
Lifestyle modification represents the first‐line strategy for the prevention and treatment of
type 2 diabetes mellitus (T2DM), which is frequently associated with obesity and …

The mechanisms of the development of atherosclerosis in prediabetes

Y Liang, M Wang, C Wang, Y Liu, K Naruse… - International journal of …, 2021 - mdpi.com
Lifestyle changes, such as overeating and underexercising, can increase the risk of
prediabetes. Diabetes is one of the leading causes of atherosclerosis, and recently it …

Diet and exercise in lifestyle medicine: The hormetic effects of bioactive compounds on human health

I Peluso - Current Opinion in Toxicology, 2022 - Elsevier
The present review aims to discuss the role of bioactive compounds in the context of the
hormetic-based lifestyle medicine. The dose–response relationships of nutritional hormetins …

Changes in proteomic cargo of circulating extracellular vesicles in response to lifestyle intervention in adolescents with hepatic steatosis

JK DiStefano, IS Piras, X Wu, R Sharma… - Clinical Nutrition …, 2024 - Elsevier
Background Recent studies suggest that proteomic cargo of extracellular vesicles (EVs) may
play a role in metabolic improvements following lifestyle interventions. However, the …

Acute exercise decreases insulin‐stimulated extracellular vesicles in conjunction with augmentation index in adults with obesity

EM Heiston, A Ballantyne, S La Salvia… - The Journal of …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are often elevated in obesity and may modulate disease risk.
Although acute exercise reduces fasting EVs in adults with obesity, no data exist on insulin …

Extracellular vesicles and insulin‐mediated vascular function in metabolic syndrome

TJ Ragland, EM Heiston, A Ballantyne… - Physiological …, 2023 - Wiley Online Library
Abstract Metabolic Syndrome (MetS) raises cardiovascular disease risk. Extracellular
vesicles (EVs) have emerged as important mediators of insulin sensitivity, although few …

Tracking Biomarker Responses to Exercise in Hypertension

E Trillaud, P Klemmer, SK Malin… - Current Hypertension …, 2023 - Springer
Abstract Purpose of Review Strong evidence is evolving that physical exercise prevents
hypertension and reduces blood pressure in patients with pre-and manifest HTN. Yet …

High-intensity functional exercise does not cause persistent elevations in augmentation index in young men and women

RQ Landers-Ramos, I Lawal, I Imery… - Applied Physiology …, 2022 - cdnsciencepub.com
Elevations in central augmentation index (AIx) are predictive of cardiovascular disease. The
objective of this study was to examine AIx immediately and 24 h following an acute bout of …

Extracellular Vesicles in Metabolic and Vascular Insulin Resistance

SK Malin, U Erdbrügger - Journal of Vascular Research, 2024 - karger.com
Background: Insulin resistance is a major etiological factor in obesity, type 2 diabetes, and
cardiovascular disease (CVD). Endothelial dysfunction may precede impairments in …

Effects of exercise on extracellular vesicles in patients with metabolic dysfunction: A systematic review

T Li, X Han, S Chen, B Wang, Y Teng, W Cheng… - Journal of …, 2023 - Springer
The aim of this study was to investigate the effect of exercise on extracellular vesicles (EVs)
in patients with metabolic dysfunction. The literatures were searched until Apr 28, 2022, and …