Intranasal drug delivery: opportunities and toxicologic challenges during drug development

LA Keller, O Merkel, A Popp - Drug delivery and translational research, 2022 - Springer
Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has
increased. This review article summarises information on intranasal administration for local …

C ell therapy for spinal cord injury with olfactory ensheathing glia cells (OEC s)

RM Gómez, MY Sánchez, M Portela‐Lomba, K Ghotme… - Glia, 2018 - Wiley Online Library
The prospects of achieving regeneration in the central nervous system (CNS) have
changed, as most recent findings indicate that several species, including humans, can …

Transplantation of nasal olfactory mucosa mesenchymal stem cells benefits Alzheimer's disease

CG Hong, ML Chen, R Duan, X Wang, ZL Pang… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is a common neurodegenerative disease that contributes to 60–
70% of dementia in elderly people and is currently incurable. Current treatments only relieve …

Autologous olfactory mucosa mesenchymal stem cells treatment improves the neural network in chronic refractory epilepsy

ZZ Liu, Y Huang, CG Hong, X Wang, R Duan… - Stem Cell Research & …, 2023 - Springer
Background and aims Refractory epilepsy is also known as drug-resistant epilepsy with
limited clinical treatment. Benefitting from its safety and easy availability, olfactory mucosa …

Comparative study of immune regulatory properties of stem cells derived from different tissues

M Di Trapani, G Bassi, M Ricciardi… - Stem cells and …, 2013 - liebertpub.com
Allogeneic stem cell (SC)-based therapy is a promising tool for the treatment of a range of
human degenerative and inflammatory diseases. Many reports highlighted the immune …

[HTML][HTML] mSWI/SNF (BAF) complexes are indispensable for the neurogenesis and development of embryonic olfactory epithelium

C Bachmann, H Nguyen, J Rosenbusch, L Pham… - PLoS …, 2016 - journals.plos.org
Neurogenesis is a key developmental event through which neurons are generated from
neural stem/progenitor cells. Chromatin remodeling BAF (mSWI/SNF) complexes have been …

The nasal cavity of the rat and mouse—source of mesenchymal stem cells for treatment of peripheral nerve injury

RD Alvites, AR Caseiro, SS Pedrosa… - The Anatomical …, 2018 - Wiley Online Library
The nasal cavity performs several crucial functions in mammals, including rodents, being
involved in respiration, behavior, reproduction, and olfaction. Its anatomical structure is …

Nasal polyposis: insights in epithelial-mesenchymal transition and differentiation of polyp mesenchymal stem cells

E Chiarella, N Lombardo, N Lobello, A Aloisio… - International journal of …, 2020 - mdpi.com
Chronic rhinosinusitis is a common inflammatory disease of paranasal sinuses, which
causes rhinorrhea, nasal congestion, and hyposmia. The genetic predisposition or the …

Anatomy of the olfactory mucosa

I Salazar, P Sanchez-Quinteiro, AW Barrios… - Handbook of clinical …, 2019 - Elsevier
The classic notion that humans are microsmatic animals was born from comparative
anatomy studies showing the reduction in the size of both the olfactory bulbs and the limbic …

Neural crest and olfactory system: new prospective

PE Forni, S Wray - Molecular neurobiology, 2012 - Springer
Sensory neurons in vertebrates are derived from two embryonic transient cell sources:
neural crest (NC) and ectodermal placodes. The placodes are thickenings of ectodermal …