Alzheimer's disease, the leading cause of dementia in the elderly, is a neurodegenerative
condition characterized by accumulation of amyloid plaques and neurofibrillary tangles in …

Alzheimer's disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ)
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …

Cerebrovascular alterations are a key feature of Alzheimer's disease (AD) pathogenesis.
However, whether vascular damage contributes to synaptic dysfunction and how it …

In Alzheimer's disease (AD), Aβ deposits form slowly, several decades before further
pathological events trigger neurodegeneration and dementia. However, a substantial …

Since the successful conquest of many acute, communicable (infectious) diseases through
the use of vaccines and antibiotics, the currently most prevalent diseases are chronic and …

Transthyretin (TTR) is a tetrameric protein transporting hormones in the plasma and brain,
which has many other activities that have not been fully acknowledged. TTR is a positive …

Alzheimer's disease (AD) is the most common neurodegenerative disease, affecting millions
of people worldwide. The classical hallmarks of AD include extracellular beta-amyloid (Aβ) …

Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily
because of association with a variety of incurable human and animal diseases (termed …

Background: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder with
important vascular and hemostatic alterations that should be taken into account during …

Transthyretin amyloidosis (ATTR) is a group of diseases caused by the deposition of
insoluble fibrils derived from misfolded transthyretin, which compromises the structure and …