Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Histone demethylase LSD1 plays key roles during carcinogenesis, targeting LSD1 is
becoming an emerging option for the treatment of cancers. Numerous LSD1 inhibitors have …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Histone lysine-specific demethylase 1 (LSD1/KDM1A) was first identified in 2004 as an
epigenetic enzyme able to demethylate specific lysine residues of histone H3, namely …

Studies of alterations in histone methylation in cancer have led to the identification of histone
methyltransferases and demethylases as novel targets for therapy. Lysine-specific …

Neuroblastoma (NB) is a pediatric cancer of the sympathetic nervous system and one of the
most common solid tumors in infancy. Amplification of MYCN, copy number alterations …

Spinobulbar muscular atrophy (SBMA) is caused by CAG expansions in the androgen
receptor gene. Androgen binding to polyQ-expanded androgen receptor triggers SBMA …

Background Alzheimer's disease (AD) is a severe neurodegenerative disorder that
progressively destroys cognitive skills. Exploring the mechanism underlying autophagic …

The development of novel therapeutic approaches is necessary to manage gastrointestinal
cancers (GICs). Considering the effective molecular mechanisms involved in tumor growth …

Calycosin, one of small molecules derived from astragalus, has anti-tumor effects in various
tumors. However, the effects of calycosin on papillary thyroid cancer (PTC) remain unclear …