Background: Skin is the interface between an organism and the external environment, and
hence the stratum corneum (SC) is the first to withstand mechanical insults that, in certain …

Tissue mechanobiology is an emerging field with the overarching goal of understanding the
interplay between biophysical and biochemical responses affecting development …

Abundant corneocyte surface protrusions, observed in patients with atopic dermatitis with
filaggrin loss-of-function mutations, are inversely associated with levels of natural …

Circadian rhythms are daily oscillations that, in mammals, are driven by both a master clock,
located in the brain, and peripheral clocks in cells and tissues. Approximately 10% of the …

Background: Linoleate-containing acylglucosylceramide (GLC-CER [EOx], where x=
sphingosine [S], dihydrosphingosine [dS], phytosphingosine (P), or 6-hydroxysphingosine …

Abstract Background The Stratum Corneum (SC) is the first barrier of the skin. The properties
of individual cells are crucial in understanding how the SC at different anatomical regions …

We evaluated the presence of tight junction (TJ) remnants in the stratum corneum (SC) of in
vitro reconstructed human epidermis and human skin explants subjected or not to an …

Atomic force microscopy (AFM) is a powerful technique for nanoscale imaging and
mechanical analysis of biological specimens. It is based on the highly sensitive detection of …

When the ancestors of men moved from aquatic habitats to the drylands, their evolutionary
strategy to restrict water loss is to seal the skin surface with lipids. It is unknown how these …

The cornified lipid envelope (CLE) is a lipid monolayer covalently bound to the outside of
corneocytes and is part of the stratum corneum (SC). The CLE is suggested to act as a …