Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …

The immune response to acute cerebral ischemia is a major factor in stroke pathobiology
and outcome. While the immune response starts locally in occluded and hypoperfused …

Alzheimer's disease (AD) is a common neurodegenerative disorder and the leading cause
of cognitive impairment. Due to insufficient understanding of the disease mechanisms, there …

Stroke remains a significant unmet clinical need with few treatment options that have a very
narrow therapeutic window, thereby causing massive mortality and morbidity in the United …

The evolution of adaptive immunity provides enhanced defence against specific pathogens,
as well as homeostatic immune surveillance of all tissues. Despite being'immune privileged' …

ST2, a member of the interleukin (IL) 1 receptor family, and its ligand IL-33 play critical roles
in immune regulation and inflammatory responses. This study explores the roles of …

Stroke is one of the leading causes of death and disability worldwide. The long‐standing
dogma that stroke is exclusively a vascular disease has been questioned by extensive …

Abstract Interleukin 33 (IL-33), which is expressed by several immune cell types, endothelial
and epithelial cells, and fibroblasts, is a cytokine of the IL-1 family that acts both intra-and …

Alterations in neuronal connectivity, particularly in the “peri-infarct” tissue adjacent to the
region of ischemic damage, are important contributors to the spontaneous recovery of …

Stroke is a lethal cerebral disease with severe sequelae and high mortality. Microglia, the
main immune cell in the cerebrum, possess therapeutic potential for strokes as its specific …