The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity.
Perturbations in either system can prompt primary pathological end points of hemorrhage or …

Atherosclerosis is an arterial disease associated with inflammation. Thrombin is a
procoagulant and proinflammatory serine protease that contributes to the pathology of …

Two of the most predominant features of the Alzheimer's disease (AD) brain are deposition
of β-amyloid (Aβ) plaques and inflammation. The mechanism behind these pathologies …

Background Nafamostat mesylate (nafamostat, NM) is an FDA-approved serine protease
inhibitor that exerts anti-neuroinflammation and neuroprotective effects following rat spinal …

Background: Injury to cells adjacent to an intracerebral hemorrhage (ICH) is likely mediated
at least in part by toxins released from the hematoma that initiate complex and interacting …

Argatroban is a synthetic thrombin inhibitor approved by US Food and Drug Administration
for the treatment of thrombosis. However, whether it plays a role in the repair of spinal cord …

Thrombin facilitates the aggregation of platelet in hemostatic processes and participates in
the regulation of cell signaling. Therefore, the development of thrombin sensors is conducive …

Spinal cord injury (SCI) will result in the significant elevation of thrombin production at lesion
site via either breakage of blood-spinal cord barrier or upregulated expression within nerve …

Purpose Although lesion dissemination in time is a defining characteristic of multiple
sclerosis (MS), there is a limited understanding of lesion heterogeneity. Currently …

Herein we describe a novel isothermal and enzyme-free electrochemical aptasensor for
protein detection via the employment of polymeric ferrocene nanoparticles (PFcNPs) and …