A beginner's guide to the characterization of hydrogel microarchitecture for cellular applications
FD Martinez-Garcia, T Fischer, A Hayn, CT Mierke… - Gels, 2022 - mdpi.com
The extracellular matrix (ECM) is a three-dimensional, acellular scaffold of living tissues.
Incorporating the ECM into cell culture models is a goal of cell biology studies and requires …
Incorporating the ECM into cell culture models is a goal of cell biology studies and requires …
Mechanism of action of collagen and epidermal growth factor: A review on theory and research methods
MH Shahrajabian, W Sun - Mini Reviews in Medicinal …, 2024 - ingentaconnect.com
The most abundant protein found in mammals is collagen, and there are around 28 different
types of collagen found in the human body, but there are five types, namely, Type I, Type II …
types of collagen found in the human body, but there are five types, namely, Type I, Type II …
Collagen microarchitecture mechanically controls myofibroblast differentiation
Altered microarchitecture of collagen type I is a hallmark of wound healing and cancer that is
commonly attributed to myofibroblasts. However, it remains unknown which effect collagen …
commonly attributed to myofibroblasts. However, it remains unknown which effect collagen …
3D in vitro M2 macrophage model to mimic modulation of tissue repair
Distinct anti-inflammatory macrophage (M2) subtypes, namely M2a and M2c, are reported to
modulate the tissue repair process tightly and chronologically by modulating fibroblast …
modulate the tissue repair process tightly and chronologically by modulating fibroblast …
The phenotype of cancer cell invasion controlled by fibril diameter and pore size of 3D collagen networks
The behavior of cancer cells is strongly influenced by the properties of extracellular
microenvironments, including topology, mechanics and composition. As topological and …
microenvironments, including topology, mechanics and composition. As topological and …
Fiber alignment drives changes in architectural and mechanical features in collagen matrices
Aligned collagen architecture is a characteristic feature of the tumor extracellular matrix
(ECM) and has been shown to facilitate cancer metastasis using 3D in vitro models …
(ECM) and has been shown to facilitate cancer metastasis using 3D in vitro models …
Effect of nuclear stiffness on cell mechanics and migration of human breast cancer cells
T Fischer, A Hayn, CT Mierke - Frontiers in cell and developmental …, 2020 - frontiersin.org
The migration and invasion of cancer cells through 3D confined extracellular matrices is
coupled to cell mechanics and the mechanics of the extracellular matrix. Cell mechanics is …
coupled to cell mechanics and the mechanics of the extracellular matrix. Cell mechanics is …
Instructing human macrophage polarization by stiffness and glycosaminoglycan functionalization in 3D collagen networks
M Friedemann, L Kalbitzer, S Franz… - Advanced …, 2017 - Wiley Online Library
Dynamic alterations of composition and mechanics of the extracellular matrix are suggested
to modulate cellular behavior including plasticity of macrophages (MPhs) during wound …
to modulate cellular behavior including plasticity of macrophages (MPhs) during wound …
Collagen fibril orientation instructs fibroblast differentiation via cell contractility
Collagen alignment is one of the key microarchitectural signatures of many pathological
conditions, including scarring and fibrosis. Investigating how collagen alignment modulates …
conditions, including scarring and fibrosis. Investigating how collagen alignment modulates …
Fibril bending stiffness of 3D collagen matrices instructs spreading and clustering of invasive and non-invasive breast cancer cells
Extracellular matrix stiffening of breast tissues has been clinically correlated with malignant
transformation and poor prognosis. An increase of collagen fibril diameter and lysyl-oxidase …
transformation and poor prognosis. An increase of collagen fibril diameter and lysyl-oxidase …