It has been long known that blood health heavily influences optimal physiological function.
Abnormalities affecting the physical properties of blood have been implicated in the …

The aim of this study was to (1) analyze blood viscosity, red blood cell (RBC) deformability,
and aggregation in hospitalized patients with Coronavirus disease 19 (COVID‐19);(2) test …

Platelets have important functions in hemostasis. Best investigated is the aggregation of
platelets for primary hemostasis and their role as the surface for coagulation leading to fibrin …

A State of the Art lecture titled “Blood Clot Contraction: Mechanisms, Pathophysiology, and
Disease” was presented at the International Society on Thrombosis and Haemostasis (ISTH) …

While blood clot formation has been relatively well studied, little is known about the
mechanisms underlying the subsequent structural and mechanical clot remodeling called …

A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and
stroke are prominent features in patients with sickle cell disease (SCD). Coagulation factor …

Blood clots and thrombi undergo platelet-driven contraction/retraction followed by structural
rearrangements. We have established quantitative relationships between the composition of …

Background Piezo1 is a mechanosensitive cationic channel that boosts intracellular [Ca 2+]
i. Compression of red blood cells (RBCs) during platelet-driven contraction of blood clots …

Mechanotransduction is the ability of cells to “feel” or sense their mechanical
microenvironment and integrate and convert these physical stimuli into adaptive …

The biomechanical properties of blood clots, which are dictated by their compositions and
micro-structures, play a critical role in determining their fates, ie, occlusion, persistency, or …