Coumarins and flavonoids are heterocyclic molecules that have been associated with
beneficial effects on human health, such as reducing the risk of cancer, diabetes …

Covering: 1959 to 2013 Silybin, a secondary metabolite isolated from the seeds of the
blessed milk thistle (Silybum marianum) was discovered as the first member of a new family …

A codrug of the anti-Alzheimer drug tacrine and the natural product silibinin was
synthesized. The codrug's biological and pharmacological properties were compared to an …

Through Hsp90-dependent firefly luciferase refolding and Hsp90-dependent heme-
regulated eIF2α kinase (HRI) activation assays, silybin was identified as a novel Hsp90 …

It has been reported that autophagy is involved in the replication of many viruses. In this
study, we screened 89 medicinal plants, using an assay based on the inhibition of the …

The synthesis of various silybin monogalloyl esters was developed, and their antiangiogenic
activities were evaluated in a variety of in vitro tests with human umbilical vein endothelial …

Many of nowadays diseases are due to the oxidative stress resulting from imbalance
between formation and neutralization of free radicals. Intake of dietary antioxidants is …

Silybin is the major flavonolignan of silymarin and it displays a plethora of biological effects,
generally ascribed to its antioxidant properties. Herein we shall describe an efficient …

The present study reports the synthesis and anticancer activity evaluation of twelve novel
silybin analogues designed using a ring disjunctive-based natural product lead (RDNPL) …

A series of neuroprotective hybrid compounds was synthesized by conjugation of the
flavonolignan silibinin with natural phenolic acids, such as ferulic, cinnamic and syringic …