Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second most common
cause of death within the next 10 years. The prognosis for this disease is poor despite …

Microsatellite instability (MSI) is a genomic alteration in which microsatellites, usually of one
to four nucleotide repeats, accumulate mutations corresponding to deletions/insertions of a …

The efficiency of DNA-enrichment techniques is often insufficient to detect mutations that
occur at low frequencies. Here we report a DNA-excision method for the detection of low …

Congenital melanocytic nevus (CMN) is a particular melanocytic in utero proliferation
characterized by an increased risk of melanoma transformation during infancy or adulthood …

KRAS gene mutations are predictive markers of non-response to anti-epidermal growth
factor receptor. An increasing number of techniques are being developed to detect KRAS …

Cancer has become a global health issue and liquid biopsy has emerged as a non-invasive
tool for various applications. In cancer, circulating tumor DNA (ctDNA) can be detected from …

The mitogen-activated protein kinase (MAPK) pathway is constantly activated in Langerhans
cell histiocytosis (LCH). Mutations of the downstream kinases BRAF and MAP2K1 mediate …

Current cancer detection systems lack the required sensitivity to reliably detect minimal
residual disease (MRD) and recurrence at the earliest stages when treatment would be most …

Detection of microsatellite-instability in colonoscopy-obtained polyps, as well as in plasma-
circulating DNA, is frequently confounded by sensitivity issues due to co-existing excessive …

Introduction: Blood draw or collection of other body fluids, known as 'liquid biopsies' are
generally less invasive procedures than tumor biopsies. Cell-free tumor DNA (ctDNA) is …