The complementary interaction of microRNAs (miRNAs) with their binding sites in the 3′
untranslated regions (3′ UTRs) of target gene mRNAs represses translation, playing a …

Pregnane x receptor (PXR) as a nuclear receptor is well-established in drug metabolism,
however, it has pleiotropic functions in regulating inflammatory responses, glucose …

Pregnane X Receptor (PXR) belongs to the nuclear receptors' superfamily and mainly
functions as a xenobiotic sensor activated by a variety of ligands. PXR is widely expressed …

Fluoropyrimidines are chemotherapeutic agents widely used for the treatment of various
solid tumors. Commonly prescribed FPs include 5-fluorouracil (5-FU) and its oral prodrugs …

Colorectal cancer (CRC) is one of the most malignant cancers in the world. A major cause of
death in CRC patients is the limited therapeutic options in its advanced stages. The …

Simple Summary There is an increasing scientific interest in the study of the interaction
between the immune system and drugs in cancer that can affect the efficacy of an anti …

Pharmacogenetics plays a key role in personalized cancer treatment. Currently, the clinically
available pharmacogenetic markers for metastatic colorectal cancer (mCRC) are in genes …

Introduction Irinotecan is a cytotoxic agent that is widely used in the treatment of several
types of solid tumors. However, although it is generally well tolerated, approximately 20% to …

Neoadjuvant chemoradiotherapy (nCRT) followed by radical surgery is the standard of care
for patients with Locally Advanced Rectal Cancer (LARC). Current selection for nCRT is …

Chronic intestinal inflammation significantly contributes to the development of colorectal
cancer and remains a pertinent clinical challenge, necessitating novel therapeutic …