Sepsis is life-threatening and often leads to acute brain damage. Dexmedetomidine, an α2-
adrenoceptor agonist, has been reported to possess neuroprotective effects against various …

Chronic cerebral hypoperfusion (CCH) is a major global disease with chronic cerebral blood
flow reduction. It is also the main cause of cognitive impairment and neurodegenerative …

Abstract Major Depressive Disorder (MDD) is a common psychiatric disorder for which
available medications are often not effective. The high prevalence of MDD and modest …

Early life adversities (stress, infection and mal/undernutrition) can affect neurocognitive,
hippocampal and immunological functioning of the brain throughout life. Substantial …

Sepsis-associated encephalopathy (SAE) is a diffuse brain dysfunction without overt central
nervous system infection. Caffeine citrate has therapeutic effect on different brain diseases …

Background The glutamine synthetase (GS), an astrocyte-specific enzyme, is involved in
lipopolysaccharide (LPS)-induced inflammation which activates the mitogen-activated …

Lipopolysaccharide (LPS) is a commonly used agent for induction of neuroinflammation in
preclinical studies. Upon injection, LPS causes activation of microglia and astrocytes, whose …

Protein malnourishment and immune stress are potent perinatal stressors, encountered by
children born under poor socioeconomic conditions. Thus, it is necessary to investigate how …

Sepsis is a clinical syndrome occurring in patients following infection or injury, and is a
leading cause of mortality in the world. However, the pathogenesis that contributes to sepsis …

Altered astrocytic function is a contributing factor to the development of neurological
diseases and neurodegeneration. Berry fruits exert neuroprotective effects by modulating …