Glioblastoma therapy: past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Tumors and cytomegalovirus: An intimate interplay

G Herbein - Viruses, 2022 - mdpi.com
Human cytomegalovirus (HCMV) is a herpesvirus that alternates lytic and latent infection,
infecting between 40 and 95% of the population worldwide, usually without symptoms …

Polyploidy, EZH2 upregulation, and transformation in cytomegalovirus-infected human ovarian epithelial cells

R El Baba, S Haidar Ahmad, F Monnien, R Mansar… - Oncogene, 2023 - nature.com
Human cytomegalovirus (HCMV) infection has been implicated in epithelial ovarian cancer
(OC). Polyploidy giant cancer cells (PGCCs) have been observed in high-grade serous …

Presence of the human cytomegalovirus in glioblastomas—A systematic review

I Peredo-Harvey, A Rahbar, C Söderberg-Nauclér - Cancers, 2021 - mdpi.com
Simple Summary Whether the human cytomegalovirus (HCMV) is present in samples
obtained from patients with glioblastoma (GBM) has been a matter under debate during the …

Cytomegalovirus and glioblastoma: a review of the biological associations and therapeutic strategies

T Yang, D Liu, S Fang, W Ma, Y Wang - Journal of clinical medicine, 2022 - mdpi.com
Glioblastoma is the most common and aggressive malignancy in the adult central nervous
system. Cytomegalovirus (CMV) plays a crucial role in the pathogenesis and treatment of …

Human cytomegalovirus hijacks host stress response fueling replication stress and genome instability

JM Merchut-Maya, J Bartek Jr, J Bartkova… - Cell Death & …, 2022 - nature.com
Viral infections enhance cancer risk and threaten host genome integrity. Although human
cytomegalovirus (HCMV) proteins have been detected in a wide spectrum of human …

Indirect effects of cytomegalovirus infection: Implications for vaccine development

P Moseley, P Klenerman… - Reviews in Medical …, 2023 - Wiley Online Library
Abstract Development of a cytomegalovirus (CMV) vaccine is a high priority due to its
significant global impact—contributing to mortality in immunosuppressed individuals …

Valganciclovir as add-on to second-line therapy in patients with recurrent glioblastoma

MR Pantalone, A Rahbar, C Söderberg-Naucler… - Cancers, 2022 - mdpi.com
Simple Summary Patients with glioblastoma have a dismal prognosis. The major challenge
with this disease is that it recurs despite aggressive first-line therapy and rapidly becomes …

SOX2 downregulation of PML increases HCMV gene expression and growth of glioma cells

L Wen, XZ Wang, Y Qiu, YP Zhou, QY Zhang… - PLoS …, 2023 - journals.plos.org
The presence of human cytomegalovirus (HCMV) in glioblastoma (GBM) and improved
outcomes of GBM patients receiving therapies targeting the virus have implicated HCMV in …

Valganciclovir as add-on to standard therapy in secondary glioblastoma

G Stragliotto, MR Pantalone, A Rahbar… - Microorganisms, 2020 - mdpi.com
Patients with glioblastoma have a very poor prognosis despite aggressive therapeutic
strategies. Cytomegalovirus has been detected in> 90% of glioblastoma tumors. This virus …