Epitope landscape in autoimmune neurological disease and beyond

I Talucci, HM Maric - Trends in Pharmacological Sciences, 2024 - cell.com
Autoantibody binding has a central role in autoimmune diseases and has also been linked
to cancer, infections, and behavioral disorders. Autoimmune neurological diseases remain …

Predicting the future of autoimmune encephalitides

M Guasp, J Dalmau - Revue Neurologique, 2024 - Elsevier
The concept that many neurologic and psychiatric disorders of unknown cause are immune-
mediated has evolved fast during the past 20 years. The main contribution to the expansion …

[HTML][HTML] Ketamine alleviates NMDA receptor hypofunction through synaptic trapping

F Villéga, A Fernandes, J Jézéquel, F Uyttersprot… - Neuron, 2024 - cell.com
Activity-dependent modulations of N-methyl-D-aspartate glutamate receptor (NMDAR)
trapping at synapses regulate excitatory neurotransmission and shape cognitive functions …

Converging synaptic and network dysfunctions in distinct autoimmune encephalitis

D Hunter, M Petit-Pedrol, D Fernandes, N Bénac… - EMBO …, 2024 - embopress.org
Psychiatric and neurological symptoms, as well as cognitive deficits, represent a prominent
phenotype associated with variable forms of autoimmune encephalitis, regardless of the …

Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability

J Sell, V Rahmati, M Kempfer, SR Irani… - Neurology …, 2023 - AAN Enterprises
Background and Objectives Autoantibodies to leucine-rich glioma inactivated protein 1
(LGI1) cause an autoimmune limbic encephalitis with frequent focal seizures and …

Human-derived monoclonal autoantibodies as interrogators of cellular proteotypes in the brain

ML Baum, CM Bartley - Trends in Neurosciences, 2024 - cell.com
A major aim of neuroscience is to identify and model the functional properties of neural cells
whose dysfunction underlie neuropsychiatric illness. In this article, we propose that human …

Diverse anti-NMDAR autoantibodies from individuals with encephalitis

Z Jamet, F Villega, L Groc - Nature Structural & Molecular Biology, 2024 - nature.com
Autoantibodies targeting glutamatergic N-methyl-d-aspartic acid receptors (NMDARs) are
found in people with anti-NMDAR encephalitis. Two studies reveal that patient-derived …

Mechanisms of autoimmune encephalitis

C Papi, C Milano, M Spatola - Current Opinion in Neurology, 2024 - journals.lww.com
Mechanisms of autoimmune encephalitis : Current Opinion in Neurology Mechanisms of
autoimmune encephalitis : Current Opinion in Neurology Log in or Register Subscribe to …

[HTML][HTML] Strategies to improve autoimmune neurological diseases treatment

F Leypoldt - Revue Neurologique, 2024 - Elsevier
There is a need to improve therapies in autoimmune neurologic conditions. Yet which
strategic objectives are required, what are the barriers that stand before reaching them, and …

Chaihu Guizhi Decoction prevents cognitive, memory impairments and sensorimotor gating deficit induced by N-methyl-d-aspartate receptor antibody in mice

X Zhu, Y Huang, J Qiu, Z Zhong, Y Peng… - Journal of …, 2025 - Elsevier
Ethnopharmacological relevance Anti-NMDAR encephalitis is one of the most common
types of autoimmune encephalitis, primarily presenting with prodromal symptoms, such as …