Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

Amyotrophic lateral sclerosis (ALS) is a heterogeneous motor neuron disease for which no
effective treatment is available, despite decades of research into SOD1-mutant familial ALS …

Spinal cord injury leads to a massive response of innate immune cells in non-regenerating
mammals, but also in successfully regenerating zebrafish. However, the role of the immune …

The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is
regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle …

Unlike adult mammals, zebrafish regenerate spinal cord tissue and recover locomotor ability
after a paralyzing injury. Here, we find that ependymal cells in zebrafish spinal cords …

The diverse functions of glial cells prompt the question to which extent specific subtypes may
be devoted to a specific function. We discuss this by reviewing one of the most recently …

In all vertebrate species studied thus far, the adult central nervous system harbors neural
stem cells that sustain constitutive neurogenesis, as well as latent neural progenitors that …

Motor neuron diseases (MNDs) are an etiologically heterogeneous group of disorders of
neurodegenerative origin, which result in degeneration of lower (LMNs) and/or upper motor …

The adult central nervous system (CNS) of the zebrafish, owing to its enrichment in
constitutive neurogenic niches, is becoming an increasingly used model to address …