The cilium, once considered a vestigial structure, is a conserved, microtubule-based
organelle critical for transducing extracellular chemical and mechanical signals that control …

Cilia and flagella serve as cellular antennae and propellers in various eukaryotic cells, and
contain specific receptors and ion channels as well as components of axonemal …

The assembly and maintenance of most cilia and eukaryotic flagella depends on
intraflagellar transport (IFT), the bidirectional movement of multi-megadalton IFT trains along …

Intraflagellar transport (IFT), which is essential for the formation and function of cilia in most
organisms, is the trafficking of IFT trains (ie assemblies of IFT particles) that carry cargo …

Tubulin enters the cilium by diffusion and motor-based intraflagellar transport (IFT).
However, the respective contribution of each route in providing tubulin for axonemal …

The trafficking of components within cilia, called intraflagellar transport (IFT), is powered by
kinesin-2 and dynein-2 motors. Loss of function in any subunit of the heterotrimeric …

Intraflagellar transport (IFT), a bidirectional intracellular transport mechanism in cilia, relies
on the cooperation of kinesin-2 and IFT-dynein motors. In Caenorhabditis elegans …

Eukaryotic cilia are microtubule-based organelles that protrude from the cell surface to fulfill
sensory and motility functions. Their basic structure consists of an axoneme templated by a …

Various super-resolution imaging techniques have been developed to break the diffraction-
limited resolution of light microscopy. However, it still remains challenging to obtain three …

Primary cilia are microtubule-based sensory organelles whose dysfunction causes
ciliopathies in humans. The formation, function, and maintenance of primary cilia depend …