Background In the past two decades, many legislative and regulatory initiatives were taken
globally to improve drug use in children. However, children are still found to be prescribed …

Off-label prescribing is widespread among pediatricians, and it is unlikely that this trend will
soon be bound by a uniform legal framework. This is necessitated by the fact that there are …

Background Population pharmacokinetic evaluations have been widely used in neonatal
pharmacokinetic studies, while machine learning has become a popular approach to solving …

Introduction Off-label (OL) and unlicensed (UL) drug use is widely developed in the pediatric
population according to previous reviews published in the early 2010s. The present study is …

Rational prescribing is challenging in neonatology. Drug utilization studies help identify and
define the problem. We performed a review of the literature on drug use in neonatal units …

To date, up to 65% of drugs used in neonates and infants are off-label or unlicensed, as they
were implemented in clinical care without the usual regulatory phases of pharmacological …

Background Off-label and unlicensed prescriptions pose a severe safety concern among the
pediatric population. We aimed to summarize the up-to-date evidence on the extent …

Comment www. thelancet. com Vol 396 September 26, 2020 873 can be used to design
clinical trials or inform clinical decisions regarding drug dosage. Thus, commonly used …

Aims The aim of this research is to study the prevalence of prescribing medicines for off‐
label (OL) use and unlicensed (UL) medicines for children during hospitalization in 2021 …

Background: Unlicensed and off-label (UL/OL) prescriptions have been associated with an
increased risk of drug-related problems. Data of their prevalence at hospital discharge …