Insulin signalling in the central nervous system regulates energy homeostasis by controlling
metabolism in several organs and by coordinating organ crosstalk. Studies performed in …

Insulin acts on the CNS to modulate behaviour and systemic metabolism. Disturbances in
brain insulin action represent a possible link between metabolic and cognitive health …

Insulin action in the human brain modulates eating behaviour, whole-body metabolism and
body fat distribution,. In particular, brain insulin action increases whole-body insulin …

OBJECTIVE Insulin action in the human brain reduces food intake, improves whole-body
insulin sensitivity, and modulates body fat mass and its distribution. Obesity and type 2 …

The intranasal (IN) route enables the delivery of insulin to the central nervous system in the
relative absence of systemic uptake and related peripheral side effects. Intranasally …

Insulin is a peptide well known for its role in regulating glucose metabolism in peripheral
tissues. Emerging evidence from human and animal studies indicate the multifactorial role of …

Type 2 diabetes and major depressive disorder (MDD) are the leading causes of disability
worldwide and have a high comorbidity rate with fatal outcomes. Despite the long …

BACKGROUND Insulin resistance of the brain can unfavorably affect long-term weight
maintenance and body fat distribution. Little is known if and how brain insulin sensitivity can …

Objective Activity in the dopaminergic pathways of the brain is highly sensitive to body
weight and metabolic states. Animal studies show that dopamine neurons are important …

Consolidating evidence on the role of insulin resistance in... : Current Opinion in Psychiatry
Consolidating evidence on the role of insulin resistance in major depressive disorder : Current …